Depression and Dry Eye: Understanding the Connection


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When you think about depression, you might imagine overwhelming sadness, low energy and feelings of hopelessness, whereas dry eye disease may seem like a simple eye irritation. However, research is increasingly showing that these two conditions are closely intertwined with a bidirectional relationship—each may influence and even worsen the other. In this article, we’ll explore how depression and dry eye can affect each other, the evidence behind their connection, and the implications for your overall wellbeing. Associated Eye Physicians & Surgeons of NJ proudly offers eye care at four convenient locations: Belleville serving Essex County, Rahway serving Middlesex and Union Counties, Jersey City serving Hudson County, and Union serving Union County.

Dr. Amanda Gredzik is an optometrist with a strong focus on therapeutic eye care, specializing in dry eye treatment, including the use of amniotic membranes and punctal plugs.
How Depression May Influence Dry Eye Symptoms
Depression can alter your daily routines, which in turn can affect your eye health. For example, individuals with depression may spend more time in front of screens, have irregular sleep patterns, or may not engage in routine self-care, all of which can lead to an increase in dry eye symptoms. Studies, including the one published in JAMA Ophthalmology in March 2022, have found that patients who screen positive for depression tend to report more severe symptoms of dry eye.
The mechanism behind this connection is in part behavioral and in part physiological. Depression can lead to changes in hormone levels and inflammation, both of which are known to affect the quality and quantity of your tears. Additionally, when you are depressed, you might be less likely to notice or properly manage mild eye irritation, which can escalate into a more significant dry eye problem.





How Dry Eye Can Impact Mental Health
Dry eye disease is much more than just an annoying irritation—it can significantly disrupt your quality of life. Persistent dryness, burning, blurry vision, and the feeling of a foreign body in the eye can interfere with everyday activities such as reading, driving, or even enjoying leisure time. This constant discomfort can lead to frustration and may contribute to feelings of sadness and isolation, which are common in depression.
A comprehensive umbrella review published in Frontiers in Public Health in November 2022 has highlighted that the symptoms of dry eye directly affect daily living, thereby impacting mood and overall mental wellbeing. When dry eye symptoms dictate what activities you can safely perform, they affect your social interactions and can potentially slow down work productivity or hobbies, deepening feelings of depression.

Scientific Evidence for the Relationship
Multiple studies have provided compelling evidence for a link between dry eye and depression. In one significant study, a total of 36.7% of the participants reported experiencing dry eye symptoms while 23.7% were diagnosed with depression, anxiety, or stress. Researchers found that among patients with moderate to severe dry eye disease, those with depression often exhibited even more pronounced dryness and discomfort.
Researchers believe that this relationship could be explained by several overlapping factors. For one, some antidepressant medications are known to reduce tear production, directly worsening dry eye symptoms. Moreover, the physical discomfort of dry eye might increase psychological stress, setting off a vicious cycle that perpetuates both conditions.





How Lifestyle and Behavioral Factors Play a Role
Your daily habits can often be the bridge between mental health and eye health. For example, if you spend long hours looking at a computer screen without taking breaks, you may strain your eyes and reduce your blink rate, leading to poor tear distribution and resulting in dry eye symptoms. If you are suffering from depression, these habits can become even more pronounced because of reduced motivation to change daily routines.
Moreover, depression can lead to changes in your sleep pattern. Poor sleep quality not only affects your mental health but also deprives your eyes of the rest they need to maintain an adequate tear film. This combination of behavior changes creates a perfect storm where both dry eye and depression feed into each other.
Impact on Quality of Life
Both depression and dry eye significantly affect your quality of life, albeit in different ways. Dry eye can make simple tasks like reading, driving, or using digital devices frustrating and even painful. On the other hand, depression can diminish your pleasure in activities you once enjoyed, making you feel isolated or hopeless.
When these two conditions co-exist, their combined impact can be profound. The discomfort from dry eye may limit an individual’s ability to perform daily activities, which can then lead to feelings of frustration and a worsening mood, further fueling depressive symptoms. This interplay suggests that treating dry eye might have downstream benefits for mental health, and vice versa.


Key Takeaways
The link between depression and dry eye is complex and bidirectional. On one hand, depression can increase the reporting and severity of dry eye symptoms through both physiological changes and altered daily habits. On the other hand, the constant discomfort and restrictions imposed by dry eye can negatively impact your mental health, sometimes leading to or worsening depression.
Your Trusted Eye Doctors Serving Central and Northern NJ
At Associated Eye Physicians & Surgeons of New Jersey, we understand the profound impact that both dry eye and depression can have on your life. Our eye doctors are dedicated to providing comprehensive care that addresses both conditions holistically. If you’re experiencing symptoms of dry eye or depression, we invite you to take the first step towards improved wellbeing. Experience personalized, expert eye care by scheduling an appointment with our eye doctors in Belleville, Jersey City, Rahway, or Union, NJ.
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- Demodex Blepharitis
- Depression and Dry Eye
- Dry Eye in Older Adults
- Preservative-Free Eye Drops
- Punctal Occlusion
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- Dry Eye and Tear Film Stability
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- The Nuances of Eye Drops
- Dry Eye Syndrome and Its Impact on Vision
- Understanding Dry Eye: Beyond Insufficient Tears
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- Blinking Exercises for Dry Eye Relief
- Antidepressants and Dry Eye
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- Oral Contraceptives and Dry Eye
- Contact Lens Induced Dry Eye (CLIDE)
- Removing Makeup With Dry Eye
- Lacrimal Probing
- Amniotic Membranes
- Finding the Best Eye Drops for Dry Eyes
- Chalazion Removal for Dry Eye
- Conjunctivitis or Dry Eye?
- Excessive Tearing and Dry Eye
- Foreign Body Sensation in Dry Eye
- How to apply eye drops for dry eye?

At Associated Eye Physicians & Surgeons of New Jersey, we proudly serve Northern and Central New Jersey through four convenient locations. Our Belleville office cares for patients in Essex County, including Newark, Bloomfield, and Nutley. The Rahway location serves Middlesex and Union Counties, including Elizabeth, Avenel, Woodbridge, and Perth Amboy. In Union, we see patients from Union County, including Elizabeth and Cranford. And our Jersey City office welcomes Hudson County residents from Hoboken, Bayonne, and beyond.